Peptides

treatment of bacterial keratitis

Esculentin 1a derived peptides for treatment of microbial keratitis

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We discovered that Esc peptides are highly efficient in reducing the level of infection in a mouse model of keratitis upon local administration in a drop-wise fashion. Our current aim is the development of our peptides as new ophthalmic agents for treatment of bacterial keratitis, as well as to produce antimicrobial contact lenses for preventative …

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Polymeric nanoparticles petide deliver at lung

Polymeric nanoparticles: a promising formulation for peptide delivery at lung

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We recently demonstrated that encapsulation of Esc peptides inside engineered biodegradable polymeric nanoparticles (NPs) made of poly(lactic-co-glycolic) acid is an excellent strategy (i) to overcome lung barriers (i.e. the sticky mucus lying the airways epithelia, mostly in cystic fibrosis), that usually interfere with the antibiotic treatment and (ii) to prolong the in vitro/in vivo antimicrobial …

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